Microscopic Description:

The specimens are characterized by poorly demarcated and nonencapsulated proliferation of atypical ovoid to spindloid cells. These cells are proliferating as solid sheets in a disorganized pattern and are notably invasive into underlying connective tissue structures. Individual cells are characterized by moderate eosinophilic cytoplasm and moderately pleomorphic euchromatic nuclei. There is less than one mitotic figure per high power field, although mitotic figures are found within the mass.

Diagnosis:

Malignant neoplasia. Poorly differentiated. Undetermined histogenic origin.

Comments:

Due to the poorly differentiated nature of the neoplasm, definite histogenic origin is uncertain. Based on cytomorphological features, poorly differentiated squamous cell carcinoma, or poorly differentiated malignant amelanotic melanoma should be considered.

Based on the information above, how long can we expect to have with Geez? Ishe in any pain now or will he be later? What can we expect? Doc could not really give me an answer to these questions. Hoping someone here can.

Thank you,
Mary

[from: Bruce H. Williams, DVM, DACVP]

Dear Mary -

No one can give you an answer, because the type of tumor has not been identified. If we know what type of tumor it is (or as this pathologist says, the histogenic origin), then we could say, because each tumor type has a characteristic behavior and prognosis.

One problem here, is that I don't see where the tumor was located. Going just on this report, I would probably have to add lymphoma to the list, as it would also fit this cellular description.

I would be happy to look at this case if your vet will call the lab and have them forward the material to me. (I work with a lot of the labs on ferret cases.) I will need a slide and the paraffin block of the tumor that it was taken from. With poorly differntiated tumors, often special tests (called immunohistochemical tests) are run to identify markers for various cell types. Very few labs run these, as they are expensive, and most labls simply look at the slide and make their best educated guess.

I have a number of immunohistochemical tests at my disposal, and if I can get the appropriate material, perhaps I can make a more definitive diagnosis, and then, be able to answer your question.

With kindest regards,
Bruce H. Williams, DVM, DACVP
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